activated protein c resistance การใช้

• Activated protein C resistance occurs when APC is unable to perform its functions.
• There have also been cases in patients with other deficiency, including protein S deficiency, activated protein C resistance ( Factor V Leiden ) and antithrombin III deficiency.
• Patients with Down syndrome, sickle cell anemia, neurofibromatosis type 1, congenital heart disease, fibromuscular dysplasia, activated protein C resistance, or head trauma can develop moyamoya malformations.
• Activated protein C resistance is the inability of protein C to cleave Factor Va and / or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state.
• The most common mutation leading to activated protein C resistance among Caucasians is at the cleavage site in Factor V for APC . There, Arg 506 is replaced with Gln, producing Factor V Leiden.
• Recurrent miscarriage is an indication for thrombophilia screening, particularly antiphospholipid antibodies ( anti-cardiolipin IgG and IgM, as well as lupus anticoagulant ), factor V Leiden and prothrombin mutation, activated protein C resistance and a general assessment of coagulation through an investigation known as thromboelastography.